Most Affordable GLP-1 Without Insurance (2026 Comparison & High Savings Guide)

If you have been prescribed a GLP-1 medication like Wegovy, Zepbound, or Ozempic, you’ve likely experienced “sticker shock.” Without insurance coverage, these “miracle” weight loss drugs can cost upwards of $1,000 to $1,300 per month.

For most people, that is simply not sustainable.

The good news? You don’t have to pay retail prices. By utilizing telehealth platforms, compounded pharmacies, and manufacturer savings programs, you can access the most affordable GLP 1 options for as low as $199–$399 per month.

In this guide, we break down the top-ranked providers for 2024 based on cost, reliability, and clinical support.

At a Glance: Top 3 Affordable GLP-1 Providers

Provider	Monthly Starting Cost	Best For…	Link
MEDVi GLP-1	$190 – $250	Lowest Price & Fast Access	Check Eligibility
MyStart GLP-1	$254 (Flat Rate)	No Price Increases as Dosage Goes Up	Check Eligibility
DirectMeds GLP1	$297	Most Trusted Reputation	Check Eligibility

1. Compounded Semaglutide: The Most Affordable Option “MyStart GLP-1“

If your insurance denies coverage, Compounded Semaglutide (the active ingredient in Wegovy and Ozempic) is currently the most cost-effective path.

Because of the ongoing FDA drug shortage, state-licensed compounding pharmacies are legally permitted to produce these medications.

• Average Cost: $199–$300 per month (includes doctor’s visit).
• Effectiveness: Clinical studies show Semaglutide can lead to an average of 15% body weight loss.
• Best Provider: Sesame Care or Mochi Health.

2. DirectMeds Compounded Tirzepatide: The “Gold Standard” for Weight Loss

Tirzepatide (the active ingredient in Zepbound and Mounjaro) is widely considered more effective than Semaglutide, with users losing up to 22.5% of their body weight.

While the brand-name Zepbound costs $1,050+ out of pocket, compounded versions are significantly cheaper.

• Average Cost: $350–$450 per month.
• Best Provider: OrderlyMeds or Mochi Health (Mochi is famous for not charging more when your dose increases).

Detailed Rankings: Where to Buy the Cheapest GLP-1s

Based on the latest data from the , here are the top-rated platforms for affordability:

The 7 Most Affordable GLP 1 Without Insurance (Ranked)

1. 🥇 Best Overall: Zepbound via Direct-Pay Programs (Triple-Action Option)

👉 Check DirectMeds Prices →

DirectMeds GLP1 stands out for its high-level medical monitoring, ideal for users who want the most detailed guidance.

Best for Fast Appetite Reduction: Outstanding for cutting cravings early.

Access to U.S. based doctors 24/7 and No Insurance required. No Hidden Fees.

Typical cost: $149–$499/month

Zepbound is FDA-approved specifically for weight loss. While retail prices exceed $1,000, some manufacturer-supported direct-pay programs significantly reduce the cost for uninsured patients.

Pros

• FDA-approved for weight loss
• Predictable dosing
• Strong clinical data

Cons

• Still more expensive than compounded options
• Availability depends on program eligibility.

2. 🥈 Runner-Up: Compounded Tirzepatide (Dual-Action Option)

👉 Check MyStart GLP-1 Price →

MyStart GLP-1 is ideal for anyone who struggles with intense cravings, overeating, or emotional eating. Their GLP-1 program focuses on rapid appetite suppression using medically guided dosages. Best for Maximum Fat Loss and Metabolic Efficiency.

Typical cost: $199–$400/month

Excellent for consistent weekly weight-loss and appetite control, Access to U.S. based doctors 24/7 and No Insurance required. No Hidden Fees.

Compounded tirzepatide mimics the active ingredient in Zepbound and Mounjaro and targets both GLP-1 and GIP receptors, which may enhance appetite control.

Pros

• Strong appetite suppression
• Lower cost than brand Zepbound
• No insurance required
• Prescription to GLP-1 (if qualified).
• No insurance. No waitlist. No hidden fees.
• Lose up to 20% of your body weight*
• Access to U.S. based doctors 24/7

Cons

• Not FDA-approved as a brand
• Availability varies

Best for: People who want a more advanced GLP-1 approach at a reduced price.

Thousands of people are losing weight with MyStart GLP-1 medications. People like you are transforming their lives, feeling better and looking their best with the help of GLP-1 (Dual-Action Option) medications.

3. 🥉Second Runner-Up: Compounded Semaglutide

👉 Check MEDVi GLP-1 Price →

MEDVi GLP-1 is the most balanced, medically supervised GLP-1 program available today. It combines FDA-approved GLP-1 medications in both injection and oral tablet options, with direct telehealth physician oversight.

Typical cost: $99–$399/month

Compounded semaglutide is currently the lowest-cost GLP-1 option available without insurance.

It contains the same active ingredient used in Wegovy and Ozempic but is prepared by licensed compounding pharmacies instead of brand manufacturers.

Pros

• Lowest monthly cost
• No insurance required
• Flexible dosing
• Only order fron the official website

Cons

• Quality depends on the pharmacy

Best for: Budget-conscious users who want GLP-1 support at the lowest possible cost.

4. Wegovy with Cash-Pay Discounts

👉 Check SYNERGY RX Prices →

SYNERGY RX GLP 1 offers some of the best pricing for GLP-1 medication while maintaining quality standards.

Typical cost: $119–$499/month (discounted)

Wegovy-Synergy rx glp 1 is one of the most widely prescribed GLP-1 drugs for weight loss. Manufacturer discounts and cash-pay options can reduce the price for uninsured users.

Pros

• FDA-approved
• Strong long-term data
• Widely prescribed

Cons

• Full retail price is very high
• Discount availability may change

5. Ozempic (Cash Price)

👉 Check BreezeMeds GLP-1 Price →

BreezeMeds GLP-1 is designed for beginners who want a safe, simple way to begin their GLP-1 journey.

Typical cost: $200–$1,050/month

Ozempic is FDA-approved for diabetes but is commonly prescribed off-label for weight management.

Pros

• Trusted brand
• Same active ingredient as Wegovy
• Consistent manufacturing

Cons

• Expensive without insurance
• Not approved specifically for weight loss

6. Rybelsus (Oral Semaglutide)

👉 Check CloudClinic GLP1 Price →

CARE BARE RX uses a unique transdermal GLP-1 delivery system — ideal for people who dislike needles or pills.

Typical cost: $900–$950/month

Rybelsus is the oral tablet version of semaglutide, making it appealing to those who prefer pills over injections.

Pros

• No injections
• FDA-approved
• Consistent dosing

Cons

• Less potent for weight loss
• High cash price

7. Trulicity (Lower-Cost GLP-1 Alternative)

👉 Check Meto GLP-1 Price →

Typical cost: $850–$990/month

Trulicity is another GLP-1 receptor agonist primarily approved for diabetes but sometimes used off-label.

Pros

• Once-weekly injection
• Long track record
• Sometimes cheaper than Wegovy

Cons

• Less effective for weight loss
• Still expensive without insurance

MEDVi GLP-1 Sesame Care (Best for Total Budget)

Sesame has emerged as a leader in affordable healthcare. They offer a “Weight Loss Management” program that connects you directly with providers who can prescribe either brand-name or compounded options.

• Why it converts: Low entry price and high trust factor (Costco partnership).
• Estimated Cost: ~$190/mo for Semaglutide.

MyStart GLP-1 Mochi Health (Best Value for High Dosages)

Most companies charge you more as your dosage increases. Mochi Health uses a flat-rate pricing model: you pay the same price for the highest dose as you do for the starting dose.

• Semaglutide: $175 (medication) + $79 (membership) = **$254/mo.**
• Tirzepatide: $325 (medication) + $79 (membership) = **$404/mo.**

DirectMeds Henry Meds (Best Reputation)

Henry Meds is one of the most established names in the telehealth GLP-1 space. Their pricing is transparent, and their customer service is top-tier.

• Cost: Starts at $297/mo.

GLP-1 Receptor Agonist Comparison Table

Medication	FDA Approval	Avg. Weight Loss	Injection	Cost (No Insurance)	Key Notes
Wegovy® (Semaglutide)	Weight loss	15–20%	Weekly	$1,300–$1,600/mo	Most studied for obesity
Zepbound® (Tirzepatide)	Weight loss	18–25%	Weekly	$1,000–$1,300/mo	Dual GIP + GLP-1
Ozempic®	Diabetes (off-label WL)	10–15%	Weekly	$900–$1,200/mo	Lower dose semaglutide
Mounjaro®	Diabetes (off-label WL)	15–22%	Weekly	$1,000–$1,200/mo	Same drug as Zepbound
Saxenda®	Weight loss	5–10%	Daily	$1,300–$1,500/mo	Daily injections
Compounded Semaglutide	Not FDA-approved	Varies	Weekly	$250–$500/mo	Pharmacy-compounded

How to Get Brand-Name GLP-1s for Less (Manufacturer Coupons)

If you prefer brand-name Zepbound or Wegovy over compounded versions, you can use Manufacturer Savings Cards.

1. Zepbound Savings Card MyStart GLP-1: If your insurance does not cover Zepbound, you may be eligible to pay as little as $550 per month (roughly 50% off retail).
2. Wegovy Savings Card DirectMeds : Similar to Zepbound, these cards can knock $200–$500 off the retail price, bringing it down to roughly $650–$850.

Note: You still need a valid prescription from a doctor to use these coupons.

How Much Weight Can You Lose on GLP-1?

Clinical Trial Results

• Wegovy®: 15–17% body weight
• Zepbound®: 18–25% body weight
• Saxenda®: 6–8% body weight

Real-World Expectations

• Month 1: Reduced appetite, early weight loss
• Months 3–6: Noticeable body changes
• 9–12 months: Peak results for most users

Results vary based on dose, adherence, diet, and genetics.

Buyer’s Guide: How to Choose the Right Provider

To ensure you aren’t overpaying, look for these three things:

1. Transparent Pricing: Does the price such as cheapest GLP-1 without insurance include the doctor’s visit, or is that an extra “membership fee”?
2. Pharmacy Accreditation: Ensure the provider uses PCAB-accredited or high-quality state-licensed compounding pharmacies.
3. Refill Ease: Some platforms make it difficult to get your next month’s supply. Stick to the “Big 3” (Sesame, Mochi, Henry Meds) for the smoothest experience.

Frequently Asked Questions (FAQ)

What is the cheapest GLP-1 without insurance?

Compounded Semaglutide is currently the cheapest GLP-1 option, starting at approximately $199 per month through platforms like Sesame Care.

Can I get Ozempic for $25 a month without insurance?

No. The “$25 per month” advertisements usually refer to people with commercial insurance coverage. Without insurance, your lowest cost will be in the $200–$400 range for compounded versions.

Is compounded GLP-1 safe?

When sourced from a reputable, state-licensed compounding pharmacy, compounded GLP-1s contain the same active ingredients as the brand-name versions. Always avoid “research chemicals” and stick to licensed telehealth providers.

Final Verdict: Which One Should You Pick?

Finally we have revealed the Most Affordable GLP 1 Without Insurance well-know brands.

• If you want the absolute lowest price: Go with [MEDVi GLP-1 Semaglutide].
• If you want the most effective medication (Tirzepatide): Go with [ MyStart GLP-1 Mochi Health].
• If you want a trusted, well-known brand: Go with [DirectMeds Henry Meds].

Check Your Eligibility & Start Your Weight Loss Journey Today

Studies/Research

Gasoyan H, Pfoh ER, Schulte R, Le P, Butsch WS, Rothberg MB. One-year weight reduction with semaglutide or liraglutide in clinical practice. JAMA Netw Open. 2024;7(9):e2433326. doi:10.1001/jamanetworkopen.2024.33326

Food and Drug Administration. FDA approves first treatment to reduce risk of serious heart problems specifically in adults with obesity or overweight.

Food and Drug Administration. Drug approval package: Victoza (liraglutide [rDNA]) injection.

Food and Drug Administration. FDA approves weight management drug for patients aged 12 and older.

MedlinePlus. Semaglutide injection.

Rentzeperi E, Pegiou S, Koufakis T, Grammatiki M, Kotsa K. Sex differences in response to treatment with glucagon-like peptide 1 receptor agonists: Opportunities for a tailored approach to diabetes and obesity care. J Pers Med. 2022;12(3):454. doi:10.3390/jpm12030454